Psycho-Babble Medication | about biological treatments | Framed
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Re: Seroquel and seratonin?? I am confused

Posted by chess on April 10, 2005, at 9:59:28

In reply to Re: Seroquel and seratonin?? I am confused, posted by D minor on April 8, 2005, at 19:58:18

Regarding anxiety, AD's take weeks to therapeutically work, why?, i've read it is because they need time to "down-regulate" serotonin receptors on the post-synaptic cells, and that this down-regulation is what causes the eventual reduction in anxiety. Someone told me once it's like a person who can't stand swimming in a cold water pool, but then they have to learn to get used to it because they need to cross the pool everyday to get anywhere, so the person tries to desensitize themselves to the cold water by repeatedly going in it until they get used to it, and AD's are like droppping buckets of ice into the pool so that the desensitization is more intense but also maybe quicker.
When i say AD's i'm talking about the SSRIs, i know other drugs like remeron actually block some serotonin receptors and do the work for you, i just don't know if that allows for a desensitization of the receptor itself.
i'm not sure if i know what i'm talking about, but i would think two ways of causing a therapeutic effect for anxiety (?and depression) is by either desensitizing (down-regulating) or blocking the post-synaptic serotonin receptors, and Seroquel blocks the S2 receptors, i'm not sure what benefit in blocking D2 receptors has (?anti-schizo), alot of these meds also effect histamine in the brain which causes a benadryl-like sedation that some people find helpful.




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