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Re: What is wellbutrin (bupropion) pharmacological

Posted by Maxime on April 8, 2005, at 15:45:53

In reply to What is wellbutrin (bupropion) pharmacologically?, posted by sdb on April 8, 2005, at 15:21:16

Hi.

Wellbutrin is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines.
It is a relatively weak inhibitor of the neuronal uptake of norepinephrine, serotonin, and dopamine, and does not inhibit monoamine oxidase.

Hope this helps.

Maxime

> I have read it should be a weak noradrenaline/serotonin/dopamine reuptake inhibitor
>
> Most say "pro sexual" effect is caused by increased noradrenaline and dopamine and antidepressant activity also.
>
> In contrast trazodone has pro libido effects (nobody knows why) and pro erection effects (everybody knows) why.
>
> (I personally dont like to much noradrenaline transmission, because of negative experience)
>
> What is true? Does somebody know something or is there some good literature/abstracts?
>
>

 

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