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Re: Peripheral opioid antagonists

Posted by jerrympls on April 6, 2005, at 19:12:53

In reply to Peripheral opioid antagonists » barbaracat, posted by ed_uk on April 6, 2005, at 15:00:24

> Hi B!
>
> >If it didn't bung me up I'd take it all the time.
>
> Interestingly, at least two peripheral opioid antagonists are in development: methylnaltrexone and alvimopan. They are effective in preventing/treating opioid-induced constipation while leaving the analgesic properties of the opioid unchanged. At the moment, many patients who take opioids such as oxycodone for the treatment of chronic pain need to take two or more laxatives on a daily basis. Lactulose + senna is a popular combination in the UK.
>
> Ed.

Luckily I have had no problems with constipation while on the hydrocodone. Haven't had to take any laxatives either.


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