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Re: reverse tardive dyskinesa upto 60 mg Jeroen

Posted by Larry Hoover on March 24, 2005, at 16:41:30

In reply to reverse tardive dyskinesa upto 60 mg, posted by Jeroen on March 24, 2005, at 13:18:35

> i cant stop thinking about this data. i want to try it if nothing has helped. what can happen when i take 60 mg?
> One doctor has found that administering the trace mineral manganese (15 mg per day) can prevent the development of TD and that higher amounts (up to 60 mg per day) can reverse TD that has already developed.

As far as I can tell, the use of manganese to treat tardive dyskinesia dates back to three papers from 1977, none with abstracts available. I can find nothing more recent than these three references. (Aside: If it worked, wouldn't the practise be commonplace today? Are the risks of toxicity too high?)

There is continuing research into a correlation between a manganese-containing enzyme (called manganese superoxide dismutase, or MgSOD) and vulnerability to tardive dyskinesia. Those with a mutant gene for this enzyme are more vulnerable to TD, probably through the toxic effects of auto-oxidation of dopamine.

Oral supplements of 15 mg/day manganese do significantly boost MgSOD at about ninety days of treatment. Shorter, high-dose treatments might be considered (like that 60 mg/day figure), but medical supervision would be a darn good idea. Symptoms of manganese toxicity are something like Parkinson's disease. People with disturbed liver function shouldn't use manganese supps, as bile is the major route of excretion for this mineral.

So, if your liver works okay, 15 mg/day oral supp is probably fine. If neuropathy develops, symptoms should resolve on discontinuation of the manganese, if you stop immediately.





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