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Re: My little theory on reboxetine.Therapeutic window?

Posted by zeugma on March 5, 2005, at 20:03:57

In reply to My little theory on reboxetine.Therapeutic window?, posted by ed_uk on March 5, 2005, at 14:27:21

Hi Ed.

Atomoxetine is believed to have a therapeutic window for the treatment of ADD.

interestingly, no such windows exist for dopaminergic treatments for ADD, hence dosing is far more empirical (as a matter of fact, it appears to be polymorphisms of the dopamine transporter gene and the D4 receptor that determine dose-response to stimulants, rather than polymorphisms of CYP enzymes).

Reboxetine antagonizes nicotinic receptors in a manner similar to bupropion, which could mean that reboxetine, like bupropion and nortriptyline, is an effective treatment for smoking cessation.

I wonder why nortriptyline has a clear therapeutic window, while its cousin desipramine does not?

And atomoxetine caused a horrible dysphoria the last few times I've tried it. Another coincidence?





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