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Zonegran for bipolar depression open study

Posted by Mr.Scott on March 3, 2005, at 23:21:58

Any noteworthy personal experiences with this one?

NEW YORK (Reuters Health) Mar 03 - The anticonvulsant zonisamide (Zonegran, Elan Corp) may aid in the treatment of bipolar depression, according to results of a small, open-label study reported in the Journal of Clinical Psychiatry for February.

Zonisamide at low doses facilitates dopaminergic and serotonergic transmission, while at higher doses it has mood-stabilizing properties, explain Dr. Amit Anand and colleagues at Indiana University School of Medicine in Indianapolis, making it a potential candidate for treating bipolar disorder.

They treated 10 patients with bipolar disorder in the depressed phase who had not tolerated or not responded to previous treatments. The dosage was initiated at 100 mg per day titrated up to a maximum of 300 mg per day.

After 8 weeks, scores on the 17-item Hamilton Rating Scale for Depression had declined significantly from a mean of 21 to 10 (p < 0.001). Dr. Anand's group also observed significant improvements in the Clinical Global Impressions-Severity of Illness and -Improvement scales (p < 0.001 for both).

"Patients had tried other medications in previous depressive episodes and reported that they felt better on zonisamide treatment," the authors note.

"Zonisamide may be a useful alternative for bipolar patients who can tolerate it and are not responding to other medications," they conclude.

J Clin Psychiatry 2005;66:195-198.


Related Links
Resource Centers

Bipolar Disorder
Management of Serious Mental Illness


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