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Re: 5-HT2C receptor antagonists » banga

Posted by Optimist on February 24, 2005, at 23:04:36

In reply to Re: 5-HT2C receptor antagonists, posted by banga on February 24, 2005, at 17:36:26

>
> > 5-ht2a/c anatagonists can reduce this effect and increase prefrontal dopamine release.
>
> >
> AHA! That is what my pdoc was referring to this morning...he stated that the Abilify causes dopamine release, and before I could ask about it, we were on another topic...so the 5ht2a antagonism is what increases dopamine...(I had just asked about this in the thread below "adderall + strattera=anxiety relief...")
>
> But isnt that curious?, as other atypical antipsychotics also are potent 5ht2a antagonists..thus on the one hand they lead to dopamine release, yet on the other potently block certain dopamine sites.....

Yeah, the D2 antagonism helps with the positive symptoms of schizophrenia whereas the 5HT2a antagonism helps with the negative symptoms. That's why the atypical AP's are so much better in that regard. The older AP's only mostly helped the positive symptoms.

Brian


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