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Re: Cymbalta (duloxetine) - report » iris2

Posted by barbaracat on February 21, 2005, at 16:29:28

In reply to Re: Cymbalta (duloxetine) - report, posted by iris2 on February 2, 2005, at 23:48:07

Iris,
You're not alone. I had quite a strange reaction to Cymbalta just recently. Long story short, prescribed Cymbalta because I'd fallen into a very severe depression. I was taking lithium and St. John's Wort which was doing fine until I hit a bad stress event.

Was leery about an AD because I'm also BP-II and had just also had a dosage change from lithium to depakote and seroquel (I was hospitalized and hence the med change), so there was a lot of med mixing going on. But with Cymbalta at 30mg I had the feeling of doing acid, colors, shifting and sliding landscapes, a 'claw' like feeling in my neck, cramping muscles, extremely emotional. My pupils were dilated and I truly felt there was an intense serotonin thing happening, as there is with psychedelics. I felt that the seroquel was not mixing well with this and didn't like it anyhow.

I ended up throwing away the Seroquel, going back on lithium and holding the Cymbalta at bay because I do feel it was doing 'something' with my mood. I felt absolutely crazy, but not depressed and there were moments of absolute delight. But I was also feeling on the verge of hysteria most of the time.

Two days ago I ditched everything and went back to lithium and St. John's. The very next day I woke up feeling just great, wonderful, as though my brain went though a chemical ECT. I don't understand this and would hate to think the Cymbalta was responsible for this reprieve and oh sh*t, I sure don't want to go back to where I was a month ago.

I'm going to start very slowly back on Cymbalta, a few grains at a time instead of the 30mg at a pop - way to strong for me. I'm interested if I'll experience those same rather extreme and bizarre effects now that my system has cleared out of the other drugs.

Does any one have any thoughts on going very slowly with this drug? Sometimes low amounts do weird things and just prolong the agony of adjustment. - Barbara


> Has anyone ever heard of getting very emotional on Cymbalta? I only took it one day and waws way out there. Need to decide whether to try again and to stay on it longer.
>
> Thanks,
>
> irene


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