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Re: Parnate withdrawal

Posted by SLS on February 9, 2005, at 20:49:53

In reply to Re: Parnate withdrawal, posted by alienatari on February 9, 2005, at 20:10:22

> In regard to stopping an MAOI my book on MAOI's that i have says this, do you think its a bit excessive? I think I will still wait about 3 weeks before i eat anything with tyramine in it.
>
> From the book: "Remember that the chemical effects of an MAOI remain in your body for as much as one to two weeks after you stop taking it. This is why you must continue to observe the drug and dietary precautions for at least two weeks after you have taken your last MAOI. I would suggest that you actually wait a bit longer."

Actually, Parnate leaves the body within hours of taking it. The influence it has in the body, however lasts for very much longer. The brief exposure to Parnate irreversibly blocks and effectively destroys every MAO enzyme it binds to. After several weeks of therapy, there is only about 10-20% of the body's enzyme left. After you stop taking the Parnate, it takes a number of days for the body to manufacture enough new enzyme to bring it back up to 100%. 14 days is a conservative period of waiting and should be appropriate of almost everyone.


- Scott

 

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