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Re: Has anyone taken more than 60 mg Cymbalta?

Posted by med_empowered on February 2, 2005, at 4:12:58

In reply to Has anyone taken more than 60 mg Cymbalta?, posted by Hopeful at last on February 1, 2005, at 23:43:54

Hey! I only take 60mgs cymbalta. The previous poster is right; even Eli Lilly's own research into the use of higher doses found no additional benefits above 60mgs, and some pretty hardcore side-effects. One of their studies used a 120mgs/day dosage to no avail...in addition, the study had a higher dropout rate. That said, try it by all means, and see what happens, just by all means keep all lab/doctor appointments, monitor your blood-pressure, etc. etc. I personally found that Tofranil (in my case, 200mgs) + Cymbalta (60mgs) worked, although there was a blood-pressure increase (I also take adderall, and tricyclics are notorious for heart-weirdness). Anyway, Cymbalta apparently has a tendency to greatly increase the blood-levels of tricyclics and other antidepressants that may be co-prescribed, so the total effect is greater than the sum of its parts, since a standard outpatient dosage level can reach blood concentrations approaching those usually found in psychiatric inaptients. There are side-effects, yes, but the combo worked for me...best of all, when I discontinued the Tofranil, the cymbalta kept working at maintaining my response AND seemed to keep withdrawal symptoms at bay, which was nice. Good luck!


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