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Re: How long does 1 wait between Nardil and Parnate?

Posted by SLS on January 13, 2005, at 20:50:49

In reply to Re: How long does 1 wait between Nardil and Parnate?, posted by mogger on January 13, 2005, at 16:27:40

> Thanks Scott,
> I was hoping he would try it again but he seems to have gone off the MAOI thing. Does Selegiline or Marplan have the same significant warnings? I am not sure if Marplan is sold in the US.

Marplan is still sold in the US. There were a few years in the mid 1990s when it wasn't. I'm not sure how much of a market share it has, but I hope the drug company is making enough off of it to continue manufacturing it. It's not a bad drug. Some doctors characterize it as being sort of a cross between Nardil and Parnate, but weaker. All the precautions when taking Marplan are the same as when taking the other two.

Selegiline is a much different drug at the dosages it is used to treat Parkinsons Disease: 5-10mg. It generally affects only one of the two types of MAO enzyme: MAO-B. However, oral dosages above 10mg can leave one vulnerable to the same food-tyramine reaction as the other MAOIs as it begins to inhibit MAO-A. Dosages used for depression are generally higher than 10mg.

A new selegiline patch (transdermal delivery - through the skin) is close to being approved by the FDA, and is intended to treat depression. I don't know what the daily dosage will equate to, but the transdermal delivery system is not supposed to cause a food-tyramine reaction, as it bypasses the digestive system. I remain cautious, however, as significant MAOI effects still reach the intestines, albeit to a much lesser extent.


- Scott

 

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URL: http://www.dr-bob.org/babble/20050113/msgs/441888.html