Posted by SLS on January 13, 2005, at 9:12:50
In reply to How long does 1 wait between Nardil and Parnate?, posted by mogger on January 12, 2005, at 21:43:11
> Hello,
> My sister was on Nardil 45 mg, stopped taking it because she had such bad side effects, then her doctor said she could start parnate exactly one week after her last dose of Nardil. When she started Parnate she took 10 mg the 1st day, 20 mg the 2nd, and 30 mg the third day. She then had a hypertensive reaction (swelling of the eyes, headache and high blood pressure, we took her to the emergency room) after taking the 30 mg and had to come off parnate. Has that happened to anyone? She didn't eat anything that tipped it off? Just curious for anyones opinion. Many thanks,
> Joseph
Hi Joseph.The prudent doctor will require a total of 14 days between the last dose of one MAOI and the first dose of the next. I believe this is more important when switching from Nardil to Parnate than the reverse. I guess there is no way to know for sure if the reaction you describes was due to an interaction between the effects of the two drugs or if it would have happened with Parnate anyway. If the Nardil showed some positive effects, I think an argument can be made that it is worth re-introducing the Parnate after two weeks using a more gradual titration. There simply is not enough data regarding the concomitant administration of Nardil + Parnate to be able to guarantee its safety. I doubt I would try it unless my doctor had already employed such a strategy in multiple cases successfully. I haven't encountered any such doctors yet.
- Scott
poster:SLS
thread:438970
URL: http://www.dr-bob.org/babble/20050113/msgs/441544.html