Posted by Elroy on January 12, 2005, at 19:45:22
In reply to Milnacipran(Ixel) or Cymbalta + D2/D3 agonist???, posted by jparsell82` on December 28, 2004, at 2:04:50
My psych doc is looking at adding Cymbalta to my current Xanax XR. Have a primary problem with anxiety and secondary with depression. Only have hesitation in some of side effects noted in other postings (sexual and nausea). Would be interested in any type of positive feedback on use of Cymbalta or various combos including Cymbalta. Also, how similar is Cymbalta to Milnacipran?
> Anyone here tried a combination of Milnacipran or Cymbalta with Dostinex or Mirapex? I think Mirapex might have more success combined with Cymbalta or Milnacipran... Mirapex alone decreases bp(for me atleast) and makes me tired.
>
> Here's 2 case reports of the Milnacipran/Cabergoline(Dostinex combo...
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14520161
>
> Also, here's an abstract on the this type of combination:
> "It is possible that duloxetine (Cymbalta), due to be FDA-licensed in 2005, and milnacipran (Ixel), available in Europe, may be more effective than venlafaxine for a segment of the population that can benefit from dual serotonin-noradrenaline reuptake inhibition. Pain-ridden and melancholic depressives in particular may respond well to this class of drug. Once again, dopaminergic augmentation may be beneficial for the naturally lethargic. Unlike venlafaxine, duloxetine exerts its more balanced serotonin and noradrenaline reuptake inhibition throughout the dosage range. Duloxetine also weakly inhibits the reuptake of dopamine, and shows minimal affinity for the histamine and cholinergic muscarinic receptors. But it takes time to separate genuine therapeutic advance from drug company hype, typically not until the patent expires."
>
> It sounds somewhat interesting to me, Duloxetine it says also weakly inhibits reuptake of dopamine... I'm not sure if Milnacipran does. Milnacipran is a little bit stronger of norepinephrine inhibitor though. Anyone tried either of these meds?
poster:Elroy
thread:434895
URL: http://www.dr-bob.org/babble/20050108/msgs/441330.html