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Dry mouth relief » ed_uk

Posted by lars1 on January 1, 2005, at 4:53:25

In reply to Re: SSRIs vs Nardil » lars1, posted by ed_uk on December 30, 2004, at 19:54:54

> You could always try desipramine again and treat the dry mouth with a parasympathomimetic drug such as pilocarpine.

That's an excellent idea! A little web searching reveals that pilocarpine is a cholinergic agonist that promotes saliva production. Its side effects are primarily from its cholinergic effect, so they would just be reversing the anticholinergic effects of the TCA. There are also a couple of alternatives available, bethanechol (Urecholine) and cevimeline (Evoxac). The only real downsides seem to be the cost and the t.i.d. dosing (or even more often, according to some postings). It's strange that they don't seem to have a sustained-release formulation available.

I'm not ready to give up the current med combo just yet, but I will definitely keep that in mind. Why didn't I hear about this from my doctor when I was taking TCA's and it would have done me some good? Actually, it may do me some good anyway, because I'm having some dry mouth problems right now.

Best regards,
Lars


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URL: http://www.dr-bob.org/babble/20041228/msgs/436264.html