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Re: Buspar mechanism of action

Posted by csc on December 16, 2004, at 1:55:52

In reply to Re: Buspar mechanism of action, posted by scott-d-o on February 12, 2004, at 23:25:44

Buspiron is a 5HT1A agonist and DA partial agonist. It has been used to treat patient in confusional or delirium state also, as trazodone does.
I have the experience to give buspirone in patient with frontal lobe syndrome with response.
It's believed that 5HT1A makes its action to enhance mesocortical but not mesolimbic dopaminergic transmission, but I do not know whthere its action sites are mesencephalum or prefrontal corteces.
I think that 5HT1A can up-regulate post-synaptic dopmine receptors in prefrontal cortex, and the receptor number correlates to the frontal lobe function. Diinhibition, impulsivity, delusion, and even anxiety may represent the dysfunction of prefrontal cortex. A good example is diffuse lewy body dementia (DLBD), in which hallucination is one cardinal symptom. Sometimes I see a hallucination as a "negative" symptom, and its because the hypofunction of frefrontal region. Therefore I would give DA agonist in combination with buspirone in treating a case of DLBD.


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