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Re: Never underestimate the pain of severe akathisia

Posted by Mistermindmasta on December 15, 2004, at 0:06:17

In reply to Never underestimate the pain of severe akathisia, posted by ed_uk on December 12, 2004, at 19:42:12

> Arch Gen Psychiatry. 1984 Nov;41(11):1036-9.
> Akathisia with haloperidol and thiothixene.
> Van Putten T, May PR, Marder SR.
> We studied the incidence of akathisia in two populations of newly admitted schizophrenic patients: one group was treated with haloperidol and the other group was treated with thiothixene hydrochloride. Within six hours after taking a 5-mg test dose of haloperidol, 40% of the patients experienced akathisia; during maintenance treatment with 10 mg of haloperidol taken at bedtime, 75% of the patients experienced akathisia by the seventh day. With thiothixene hydrochloride (0.22-mg/kg test dose; 0.44-mg/kg maintenance dose), the respective percentages were 20% and 46%. The akathisia experienced after administration of the test of haloperidol dose was not mild or inconsequential; 28% of the patients experienced moderate, 17% of the patients experienced severe, and 22% of the patients experienced very severe akathisia. Akathisia with haloperidol could not be suppressed completely in half of the patients. Treatment-resistant akathisia was experienced as anxiety and depression. We believe these tallies to be important because akathisia causes much misery and often goes undiagnosed.
> Ed.

Yeah, no doubt about it. The only time I was ever convinced I wanted to die was when I took Chlorpromazine (I never remember the name + dont feel like looking it up) for nausea even BEFORE i had any medical problems. This drug caused horrible restlessness, depression, boredom, dysphoria, insomnia. Absolutely the worst feeling I've ever felt.

Akasthisia is SEVERELY underrated as a side effect.




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