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Re: This horrible depression

Posted by Mistermindmasta on December 14, 2004, at 23:43:19

In reply to This horrible depression, posted by tensor on December 14, 2004, at 10:26:12

> Hi,
>
> this feeling of restlessness without the energy to even take a shower or take a short walk is driving me mad. I don't know if it's the depression itself, but merely the s/e of the increase of the remeron to 45mg/d that causes this. I'm bored to death, but can't relax and, for e.g., watch a movie and just laying in my sofa, can't concentrate.
> My heart is pumping faster than usual, bad sleep, problably because i take 100mg of zoloft daily. So what shall i do, every day is just another wait for the next. I will have to stick to my benzos at least they calm me down, but i don't want get addicted to a higher dose. How long can take a three time higher dose and the step down to normal without being 'caught'?
> I know this is the core problem with depression, so you all probably feel the same. But this restlessness, is it due to increased norepinephrine?
>
> Thanks for being here guys.
>
> /Mattias

The way I understand it, restlessness usually comes from dopaminergic underactivity of the nigrostriatal (motor areas) tract. This most often occurs from the use of neuroleptics which antagonize dopamine receptors non-specifically. You wouldn't need that antagonism in the motor areas of the brain (if you were taking a neuroleptic), you'd need it other areas... it's quite an unfortunate side effect. Anyway, my point is that any number of pathyways could lower dopamine levels in the motor areas enough to cause restlessness. I think that SSRI's are able to do this through too much activity at a specific serotonin receptor that innervates the motor area thus reducing dopamine activity. I'm not sure how Rememeron does this, but I suppose norepinephrine could be involved.

I just want to tell you that when I took prochlorpromazine (I think that's the name) for nausea a few years ago, the restlessness / boredom that came with it was absolutely the worst experience of my life. It was indescribably horrible, and I hope you aren't experiencing the same degree of discomfort, because I'd be tossing all those meds out the window if you felt like I did. I was supremely tired, but I was so uncomfortable that I couldn't sleep a wink. I got zero sleep in the 3 days I took it, and ended up having to punch my legs because the pain in my legs felt better than the restlessness. Wow, that was bad.

So good luck. If you're willing to stick it out with the Remeron, I hope the restlessness subsides... if you're going to lower the dose, then I'm happy for you, because I know exactly how you're feeling, and the sooner it's relieved, the better.



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Psycho-Babble Medication | Framed

poster:Mistermindmasta thread:429387
URL: http://www.dr-bob.org/babble/20041211/msgs/429732.html