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Re: neurotransmitter chart » pablo1

Posted by Larry Hoover on November 28, 2004, at 20:55:14

In reply to Re: neurotransmitter chart, posted by pablo1 on November 28, 2004, at 18:26:45

> OK so the high number means it takes more of the drug to attach to the receptors & the low numbered drugs are stronger. I wonder if this is relative to milligrams or relative to a 'typical recommended dose' which would be more meaningful. Probably it's in relation to milligrams though I'd guess so that's another thing that needs to be calculated to get anything meaningful.

It's probably more related to blood concentration, which you can get from the pharmacokinetics of the individual drug monographs.

> I didn't see many options for norepenephrine, I used a search of 'adrenergenic%' and assume maybe I chose the correct term. Maybe it should have been '%adren%' to capture other possibilities.

There's only one reference for norepinephrine, the norepinephrine transporter. If you pull down the menu on the right hand side of query page, you can see all the different receptors for which there are data.

> Then you'd have to look up the seratonin effects & work a little formula to figure dosage and relative effect of the three (and others...) The chart I've been using is at http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html and it's very helpful but much simplified. It would be very doable to use the data on the above site and crunch it down into a really usable chart like the one I just mentioned only with real numbers that relate to a typical dose.

This database is not really for the average person's interest. It's strictly comparisons of receptor affinities, not drug effectiveness.

> Maybe add rows if the effects are different at different doses like amisulpride increases dopamine at low doses & blocks it at high doses. When I was going on effexor I wanted to know the effects of dopamine & norep. but the pharmacist was helpless to give any meaningful answers. Of course then each drug effects a different part of the brain more or less so it becomes terribly complicated. No wonder the pdocs just throw something at you & see if it works. Terribly complicated stuff.

Understatement.

Lar

 

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