Posted by SLS on November 21, 2004, at 7:01:21
In reply to Re: Rare psychotropics » SLS, posted by cubbybear on November 21, 2004, at 4:56:56
> > > > I've taken Moclobemide, a reversible MAOI anti-depressant that isn't available in the U.S. but available in many other nations of the world. I live in Bangkok. My experience with this drug was awful--it made my depression worse.
> >
> > I had a similar experience with moclobemide. It made my depression dramatically worse. I was immobilized by it. I spent all day lying on the couch curled up in the fetal position and wimpering. It was horrific.
> >
> >
> > - Scott
>
> Hi Scott,
> I know that I'm going off the orginal thread but I've always been curious about this. If I recall, you have responded well to Parnate or Nardil, correct? I wonder if there's any correlation or pattern, that people who have (previously) done well on an irreversible MAOI, do very badly on the reversible ones like Moclobemide. Any ideas?
> cubbybearYes, I have done better on Parnate and Nardil than I have on most other drugs. Off hand, I can't think of any reason why response to the irreversibles would be an index of exacerbation by the reversibles. I have, however, run across a Medline abstract that reports moclobemide reducing the dopamine content of an area of the brain that I can't remember. My guess is that this is the mechanism by which it exacerbates depression in some people.
How are you doing?
- Scott
poster:SLS
thread:417929
URL: http://www.dr-bob.org/babble/20041118/msgs/418542.html