Posted by SLS on November 9, 2004, at 10:39:05
In reply to Re: The Forbidden Combination: My AD list, posted by darkhorse on November 9, 2004, at 8:31:57
> As for Septiline ,I took it while in Japan(I do not remember the brand name),as an addition to Fluoxetine,and all I know it it is very similar in action to Mianserin& Mirtazapine (5ht2,H2,NE2)so it helped reduce my anxiety and made a better sleep and increase my appetite...
Japan also has a drug called rolipram. I'm not sure what the brand name is. It is debatable how effective it is, but its mechanism is different from anything else out there. It is a phospodiesterase inhibitor, and works on second messengers.
> How was your experience with duloxetine?
I experienced a significant antidepressant effect in the third week that disappeared quickly. I went up to 90mg, but that did very little but make me sleepy and impacted negatively on motivation.
> what other AD that is closest in effect to it,and is it worth the money and the side effects?
I would say Effexor is pretty close. As to whether or not it is worth trying Cymbalta, some people here have reported improvements in both anxiety and depression. However, the posts I have seen have lacked descriptions of the severity of depression being treated, and the degree of improvement experienced. You might want to wait a month or two more to see how Cymbalta works for people more long-term. Perhaps you can start a new thread.