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Re: Withdrawals from Pregabalin/Lyrica? » ed_uk

Posted by SLS on November 7, 2004, at 12:21:17

In reply to Re: Withdrawals from Pregabalin/Lyrica?, posted by ed_uk on November 7, 2004, at 11:14:12

Hi Ed.

> Hello...
> I didn't say that gabapentin causes a withdrawal syndrome comparable to that associated with the benzodiazepines. To be fair, withdrawal from gabapentin seems to have been very poorly studied, making it impossible to make any comparisons. As was reported, anxiety, palpitations and diaphoresis are some of the symptoms that have occured after gabapentin withdrawal. Similar symptoms are commonly seen after the withdrawal of benzos. I strongly believe that it's much too early to say that pregabalin is not associated with a withdrawal syndrome. The information that you provided may provide some reassurance but more evidence is still needed. After all, look what's become of all those other anxiolytics which were alleged to be easy to come off!!
> All the best...
> Ed


Buspar is supposed to be very forgiving upon discontinuation. It does not act upon GABA circuits directly. My guess is that any drug that acts upon the BZD GABA receptor is going to produce a robust withdrawal syndrome.

Unlike benzodiazepines and the other anticonvulsants, Neurontin and Lyrica do not act to enhance GABAergic neurotransmission. They seem to reduce excitatory events by acting as ligands upon voltage gated calcium channels (N and Q/P subtypes) to block calcium influx and inhibit neurotransmitter release. I would not expect them to produce a withdrawal syndrome similar to the BZDs in intensity.


- Scott

 

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