Posted by SLS on November 4, 2004, at 6:24:45
In reply to Gepirone, posted by Iansf on November 3, 2004, at 23:21:44
> Does anyone know why Gepirone was not approved by the FDA? I came across multiple studies demonstrating its effectiveness, but I can't uncover the reason for its rejection.
Actually, I think it was rejected for a lack of efficacy.
I was looking forward with great interest to its release and am very disappointed we will never see it.
I would have been hesitant to try gepirone because I react badly to Remeron. The metabolite of gepirone, 1-PP, is a potent antagonist of NE alpha-2 receptors, as is Remeron. You would think that this would promote an antidepressant effect for most people. However, it should be noted that Remeron also acts as an antagonist at serotonin receptors (5-HT2a and 5-HT3). This might differeniate the two and explain why gepirone is not as effective.
> The same thing happened with flesinoxan a couple years ago- very promising studies but never a release.
I know. I was even more disappointed by this outcome because flesinoxan is not metabolized into 1-PP.
Thanks for the info.
- Scott
poster:SLS
thread:411390
URL: http://www.dr-bob.org/babble/20041103/msgs/411483.html