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Re: Gepirone

Posted by SLS on November 4, 2004, at 6:24:45

In reply to Gepirone, posted by Iansf on November 3, 2004, at 23:21:44

> Does anyone know why Gepirone was not approved by the FDA? I came across multiple studies demonstrating its effectiveness, but I can't uncover the reason for its rejection.

Actually, I think it was rejected for a lack of efficacy.

I was looking forward with great interest to its release and am very disappointed we will never see it.

I would have been hesitant to try gepirone because I react badly to Remeron. The metabolite of gepirone, 1-PP, is a potent antagonist of NE alpha-2 receptors, as is Remeron. You would think that this would promote an antidepressant effect for most people. However, it should be noted that Remeron also acts as an antagonist at serotonin receptors (5-HT2a and 5-HT3). This might differeniate the two and explain why gepirone is not as effective.

> The same thing happened with flesinoxan a couple years ago- very promising studies but never a release.

I know. I was even more disappointed by this outcome because flesinoxan is not metabolized into 1-PP.

Thanks for the info.


- Scott

 

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