Posted by karaS on October 25, 2004, at 22:03:12
In reply to Re: MAOIs decrease density of DA receptors » karaS, posted by SFY on October 25, 2004, at 21:24:48
> > Ok, if it's the PEA they were referring to then the selegiline should also do the trick. (I'm assuming it would have to be taken at nonselective dosage though.)
> > I'm sure you know what your condition is between your research and your experience on various medications. I questioned you earlier about it so that I could understand from your response how we could have similar problems yet different symptoms. I find it hard to pin things down when there are several types of dopamine receptors and they occur in different areas of the brain. For instance, given that I have the hypersensitive DA receptors, you would expect that I would be anhedonic - but most of the time I'm not. I have no motivation to speak of, yet I'm usually able to find some joy in every day living. I wonder if it's possible through enough research to figure out which DA receptors one has a problem with and in which area(s) of the brain the problem exists. It probably carries no weight in terms of being able to correct the problem as the drugs we have now are not specific enough, are they?
> > Kara
> It would be nice if someone with more understanding had some way of breaking this down and at least narrowing the field of what to try. I'm anhedonic and undermotivated but selegiline (at least at the selective dosage) has no effect on me (except for the paradoxical loss of libido and sexual dysfunction). And I'm not sure what it all means.
It would be nice if we had this information to help us with all aspects of antidepressant choice. Maybe a couple hundred years from now we will (sigh).