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Re: MAOIs decrease density of DA receptors- KingVultan

Posted by Kristel on October 24, 2004, at 5:47:28

In reply to MAOIs decrease density of DA receptors- KingVultan, posted by karaS on October 24, 2004, at 5:09:36

> Todd,
>
> Thought you might like to see this abstract which seems to confirm what you've been saying. Here's the key sentence from it:
>
> "MAOI antidepressants induced a decrease in the density of both D1-like and D2-like DA receptors."
>
> Here's the link:
>
> http://www.chocolate.org/peadep.htm
>
> Kara

And that is a negative thing to happen ?!!

In fact the opposite might be true. Decrease in receptos density mean down-regulation which is thought of as the anti-depressant mechanism of these drugs. Decrease in density means increase in sensitivity of the receptors.


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poster:Kristel thread:406550
URL: http://www.dr-bob.org/babble/20041024/msgs/406555.html