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propityline- a new AD? » karaS

Posted by zeugma on October 17, 2004, at 11:59:14

In reply to Re: corrections - what was I thinking?, posted by karaS on October 17, 2004, at 4:21:27

> I'm having a rare moment of clarity and wanted to make some changes to my last couple of posts in this thread.
>
> - First of all, I confused anticholinergic with antithistaminic when discussing cholinergic urticaria.

O.K. But thanks for making me break out my dictionary :)
>
> - I forgot that Amisulpride was an AP.
>
Did you? I didn't notice any confusion on your part.

> - Thanks for recognizing that I meant protriptyline when I typed propityline.
>
"Propityline" might make me more self-pitying. But I would REALLY pity myself if I even noticed that's what you typed :)

> - After looking at Scott's chart, I can see now why you compared Cymbalta with imipramine. I hadn't realized earlier that imipramine has significant 5-HT reuptake inhibition as well.
>
Yes, but it's an open question as to whether Cymbalta will actually turn out to be useful in conditions that imipramine isn't. I wonder, since the tachycardia you experienced on NOR was like the tachycardia on DMI, which latter doesn't have much in the way of anticholinergic properties, if the speeded heart wasn't due to what Stahl calls 'pseudo-anticholinergic' properties, i.e. indirect anticholinergic effects mediated by NE potentiation. I think you mentioned that Effexor IR gave you tachycardia, but not XR. Did you go high enough on Effexor XR to get a significant noradrenergic effect?

-z

> k


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