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Re: Trouble sleeping - please help King Vultan

Posted by karaS on September 13, 2004, at 9:55:03

In reply to Re: Trouble sleeping - please help KaraS, posted by King Vultan on September 12, 2004, at 23:53:53

> >
> >
> > Sounds like you have it under control. What was the hype against Halcion a number of years back and why did it go out of favor for usage?
> >
> Mainly memory problems, especially in the elderly, and there was also an incident involving someone--a researcher or MD maybe?--attending a conference and using Halcion to try to combat jet lag who developed amnesia after taking a 0.5 mg dose (he couldn't even remember arriving at the hotel). This is why they stopped producing that size pill and lowered the maximum recommended dosage to 0.25 mg/night.
> >
> > One last question, when I take low dose selegiline, it sedates me a bit for several hours and then around 8 or 9 hours after I took it, I start to get the stimulation effect. Do you have any idea why it would work like that? Does that fit in with the hypersensitive dopamine autoreceptors theory?
> >
> >
> > Thanks,
> > Kara
> It might, but I don't know that much about selegiline other than it both inhibits MAO-B and produces amphetamine metabolites when taken orally, including methamphetamine. Obviously, these are relatively dopaminergic and could theoretically sedate someone who has hypersensitive dopamine autoreceptors. As far as the subsequent stimulation you describe, however, I'm afraid I don't have the understanding to provide an adequate explanation.
> Todd

Thanks, Todd. So scary about that doctor not remembering arriving at the hotel! I guess since we don't hear about that problem anymore that the dosage was the issue.





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