Psycho-Babble Medication | about biological treatments | Framed
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My Mirapex experience

Posted by rod on September 2, 2004, at 6:07:14

In reply to Mirapex?, posted by paulk on August 28, 2004, at 11:27:33

Hi folks,

I recently tried mirapex with mixed results. If I increase my dosage it works quite well for a few days. But after some days on ~1mg , anxiety, inhibition, fatigue, cognitive impairment comes up. If I upp again, it works well fo a few days again. On the long term mirapex is really much a downer for me. like (I imagine) a nasty mood stabilizer, nor up or down. like I experienced Amantadine.
Now I am off for a few days and feel better again. maybe just a rebound effect, who knows.

And now musing a little bit about theory...
What I find bothering is that Mirapex decreases cerebral blood flow. this sureley contributes to its side effects on cognition. And also stimulates Autoreceptors leading to a decrease in dopamine synthesis and release. But wait a moment, hey, isnt Noradrenaline and adrenaline made from dopamine? Does it mean that chronic Pramipexole (Mirapex) administration leads to decreased synthesis of the latter? Its this the reason why low blood pressure is a side effect of Mirapex? And why, in part, didnt work for me? hmm? And thinking about the mechanism of Abilify, a "dopamine - serotonin stabilizer". So dopamine activity also modulates serotonergic activity. Maybe also a explanation for my experience...

Well, whatever

have a nice day and thanks for listening





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