Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: NE alpha-2 antagonism + reuptake inhibitors = AD++ SLS

Posted by King Vultan on September 1, 2004, at 23:19:50

In reply to NE alpha-2 antagonism + reuptake inhibitors = AD++, posted by SLS on September 1, 2004, at 20:16:29

> Here's a neat little piece I found:
>
> Alpha2-adrenergic receptor blockade markedly potentiates duloxetine- and fluoxetine-induced increases in noradrenaline, dopamine, and serotonin levels in the frontal cortex of freely moving rats.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9375697
>
>
> This provides a nice pharmacological rationale for the use of Remeron or Buspar (with its 1-PP metabolite) as augmentors.
>
>
> - Scott


Or possibly yohimbine--alpha-2/alpha-1 selectivity ratio ~ 45:1 (at least according to some study I read once). As for Remeron, Stahl in "Essential Psychopharmacology" states "The therapeutic actions of mirtazapine are thought to be mainly mediated through its alpha 2 antagonist properties." However, mirtazapine has other things going for it; the selective alpha-2 antagonists such as yohimbine and idazoxan are rather one dimensional in comparison and have not really demonstrated any kind of robust AD effects. Remeron, OTOH, apparently does, to a large enough extent to at least be classified as an antidepressant, and demonstrating AD efficacy in many cases just being used by itself.

Todd


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:King Vultan thread:385419
URL: http://www.dr-bob.org/babble/20040830/msgs/385489.html