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Re: 2nd Q on paradoxical stim. response - z, anybody? KaraS

Posted by zeugma on September 1, 2004, at 19:41:14

In reply to Re: 2nd Q on paradoxical stim. response - z, anybody? zeugma, posted by KaraS on August 31, 2004, at 23:42:45

> And I am highly 'rejection sensitive' as well. Getting fired was no fun, besides the practical issues of having no money. The shocking thing is that provigil is actually helping with this. It's why I want to give it a trial up to 200 mg despite the side effects (and you're right, it's a moving target).

I wonder why that would be. Isn't rejection sensitivity tied more to serotonin?>>

For sure. Provigil may have serotonergetic effects as zana described in the provigil thread above, albeit not entirely pleasant ones (serotonin release followed by depletion?). In any case I spoke too soon, the past two days my 'rejection sensitivity' has been back, although not in full force (for which I'm thankful- less thankful about the midafternoon sweating and crash).

It seems we have a similar dilemma. Rejection sensitivity responds preferentially to SSRI's, and yet you describe SJW as too 'serotonergetic' for you (besides its negative effects on estrogen). I have not found SSRI's to be tolerable for the most part. I think Paxil would work best for me, as it would be least likely to induce appetite loss and insomnia, but my pdoc refused to let me try it as it would not go well with nortriptyline. Prozac caused nausea and sleeplessness, a thousand times worse than Provigil, and Zoloft was so unutterably bad that I swore off AD's for a decade. I'm not sure what happened; it may have been an allergic reaction, but my pdoc at the time was terrible and insisted that Zoloft had no s/e. It came at the end of a long series of medication trials including various stims and AD's, and soured me on meds for a long time.

Could you say a little more about adrenal fatigue? Symptoms, treatment, etc.?




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