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Re: Anyone have increased libido on ADs?

Posted by King Vultan on September 1, 2004, at 14:20:07

In reply to Anyone have increased libido on ADs?, posted by Colleen D. on September 1, 2004, at 12:41:19

> I recently increased my Effexor dosage from 150 to 225mg and have noticed a big difference in my desire to have sex. Orgasms are also more intense than they were and it takes less time to achieve them. I also started taking 50mg Doxepin as a sleep aid about a week ago. I'm wondering which AD may be having this effect on me or if it could be the combo. Has anyone experienced this or have any insight?
> Thanks!
> Colleen
> PPD, GAD and OCD

Could be one of these three things or some combination thereof:

1) Doxepin does have some ability to blockade serotonin 2A receptors, which will tend to counteract orgasm difficulties induced by serotonergic drugs like Effexor. However, this is a relatively weak effect compared to its powerful histamine blockade.

2) Effexor begins having more effect on blocking norepinephrine reuptake at dosages of 225 mg/day and above, and norepinephrine transmission is very important in the orgasm process.

3) Effexor also weakly blockades dopamine reuptake; it's theoretically possible this may have a positive effect on sexual function, again, more at higher dosages.

If I had to guess, I would say the 2nd possibility is the most likely one.





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