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Re: Ecstasy safely converted and prescribed? Larry Hoover

Posted by Dave001 on August 31, 2004, at 8:56:43

In reply to Re: Ecstasy safely converted and prescribed? verne, posted by Larry Hoover on August 29, 2004, at 20:31:34

<snip>

---- begin quote ----
> The first abstract below demonstrates this relationship nicely. Note that the threshold for brain damage, or even abnormal brain chemistry post-use, is greater than 4 mg/kg (by interperitoneal injection, not oral), a dose three times the typical human dose, employing a route of intake not normally employed by humans. Only
----- end quote -----

The study you're quoting involves rats. You can't directly compare animal doses to human doses without first calculating the human equivalent dose (HED) which takes into account such things as body surface area. To get the HED for rats you should multiply the dose above by 0.16. So 4 mg/kg * 0.16 = 0.64 mg/kg. That's a total dose of only 38.4 mg in your 60 kg human. Repeated dosing of MDMA and amphetamines gets even more complicated because rats metabolize the drug so much faster than humans.

Dave

<snip>


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URL: http://www.dr-bob.org/babble/20040830/msgs/384630.html