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Re: 2nd Q on paradoxical stim. response - z, anybody?

Posted by KaraS on August 29, 2004, at 19:43:50

In reply to Re: 2nd Q on paradoxical stim. response - z, anybody? KaraS, posted by zeugma on August 29, 2004, at 17:50:13

> > > hi z,
> > > >
> > > > I wonder about the longer period of time for Ritalin theory. I wonder if anyone else has had that experience. I guess I could do that experiment to find out. Re Buspar: Don't you hate it when theoretically something should work out and it doesn't? (Buspar did nothing for me but make me nauseous.) I think I need serotonin, NE and DA boosting which makes me wonder if all of my autoreceptor systems are hypersensitive or whether I just have too much MAO.
> > > >
> > > > Thanks for your input.
> > > >
> > > > Kara
> > >
> > > I have never heard of a 2-week lag to Ritalin response either. I do know that some ADHD kids get sedated from it, so what's usually done is try Adderall instead, and failing that, a second-line agent like Wellbutrin or Strattera. I *would* actually recommend Strattera, as nortriptyline stimulated you and Strattera would not cause the tachycardia, except that I developed a severe depression on it after a year. It's too bad reboxetine isn't available in the US. Cymbalta would also be a possibility....
> > >
> > > Just out of curiousity what kind of reaction do you have to caffeine? I know a few people who have a cup of coffee at bedtime, because it sedates them.
> > >
> > > -z
> >
> > Fortunately caffeine is very stimulating for me! Yay! I'd never have made it through school, grad school or work without it. Ironically, selegiline also has somewhat of a paradoxical response on me. I feel a bit tired at first (I had to drink a cup of coffee to stay awake on my temp job the other day after taking 5 mg. of it). That evening I finally felt the stimulation when I wanted to go to sleep. Adrenal fatigue might also explain some of my responses though I don't know why caffeine continues to work so well. I'm heading towards trying Cymbalta next for a variety of reasons.
> >
> > How are you doing? I seem to recall you've been having some trouble with sleep?
> >
> > Kara
> hi kara,
> yes, i've had trouble sleeping, due to Provigil, which has made me severely limit my caffeine intake. So far the limiting has had its desired effect, and I've been able to sleep a reasonable amount every night. Otherwise I've been doing better, and feeling more alert when I should be. Of course the Provigil has other s/e, which I am trying to ameliorate before my next pdoc appt. so I can discuss what would be a reasonable target dosage (generally it's 200 mg for Provigil and I think I probably need that much to function 'normally'). But the insomnia, which is absolutely intolerable, is better.
> Are you taking seligiline PRN? I'm doing that with Ritalin 10mg because I don't have much of it and am trying to see what the Provigil can do on its own. Are you finding selegiline has antidepressant properties?
> Caffeine works by entirely different mechanisms than the prescribed stims, and works even in animals whose genes have been tailored to not respond to Provigil, Ritalin, amphetamine, and anything else that you can throw at a lab rat to wake them up. Completely crazy stuff.
> -z

I'm so glad that your insomnia is under control. There's nothing worse. If you can't sleep, you can't function - as I'm sure you know only too well. How much Provigil are you taking now? I had that wierd reaction some people get to it. I felt like my limbs were made of concrete. It was so strange.

I have tried selegiline a few different times, not really as the need arises but more with the thought of trying it out for possibly taking it steadily. It would not be good on an as needed basis, since I don't get the stimulation until so many hours later. For that reason and because I think right now I may have some adrenal fatigue, I think it's best that I not take selegiline at all. Later on, when I'm feeling better and the patch comes out (fingers crossed here), I'll almost certainly try it.

That's interesting about coffee. I'm sure glad it works that way!! I've read some posts by people who drink green tea or take green tea extract (not decaf versions) and they say that they think so much more clearly than when they drink coffee and without the jitteriness of coffee. Have you read any of those posts or tried green tea? I think the last poster said that he or she takes 3 bags in a cup of hot water. Yucko on the taste but it sure sounded like it worked well for him or her.

Why doesn't Cymbalta have the side effect profile of being stimulating when it prevents the reuptake of NE? Does it have to do with the location of the reuptake?

BTW, you've often mentioned your text books and you know so much about this stuff. Are you in medical school now?





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