Psycho-Babble Medication | about biological treatments | Framed
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Re: A possible explaination.

Posted by linkadge on August 29, 2004, at 18:05:54

In reply to Re: A possible explaination. owensmar, posted by Maximus on August 29, 2004, at 17:35:38

"I can partially answer to you. Pramipexole (Mirapex) is a D3 receptor agonist. It has been proven effective in treatment-resistant depression. However it has also some drawbacks. Anger, rage and hyperactivity have also been reported as side effects."

Mirapex also activates the D2 receptor a little less potently than the D3. This *may* be more responsible for those side effects than the d3 receptor activation.

Personally I think a golden antidepressant combo would be this. Buspar and mirapex. Buspar would be the serotonin agonist at the 5-ht1a receptor and provide antidepressant activity here, as well, mirapex would hit the d3 receptors. As a bonus, the buspars d2 antagonism would block some of the mirapex's d2 receptor agonism, and perhaps some of these side effects.





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