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Re: 2nd Q on paradoxical stim. response - z, anybody? zeugma

Posted by KaraS on August 28, 2004, at 19:02:48

In reply to Re: 2nd Q on paradoxical stim. response - z, anybody?, posted by zeugma on August 28, 2004, at 17:17:54

> hi kara,
> if Todd is right, then it would take Ritalin about as long as an AD to kick in and have its desired effect (am i correct in assuming this?) btw the NE system has been posited to be in the same state of disequilibrium in melancholic depression, and imipramine has been surmised to work by desensitizing the alpha-2 autoreceptor. Studies to test this hypothesis by adding an alpha-2 antagonist to impramine or other TCA have been inconclusive or outright failures, however. Also, buspirone desensitizes the inhibitory 5HT-1A presynaptic receptor, yet it is commonly regarded as a weak drug at best.
> -z

Hi z,

I wonder about the longer period of time for Ritalin theory. I wonder if anyone else has had that experience. I guess I could do that experiment to find out. Re Buspar: Don't you hate it when theoretically something should work out and it doesn't? (Buspar did nothing for me but make me nauseous.) I think I need serotonin, NE and DA boosting which makes me wonder if all of my autoreceptor systems are hypersensitive or whether I just have too much MAO.

Thanks for your input.





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