Posted by Sad Panda on August 12, 2004, at 17:42:18
In reply to Re: Nardil insomnia and restlessness » Sad Panda, posted by Racer on August 12, 2004, at 12:51:54
> > Hi GG,
> > If your BP is low I would say that the TCA's & Trazodone would not be for you. Remeron is actually the most potent antihistamine you can get, it knocks you out pretty good for the first month you take it.
> NOT true for everyone, though. When I tried Remeron, I didn't sleep and was just out of control. Little things that might normally irritate me ENRAGED me. (And I rarely raise my voice -- just don't get worked up enough under normal circumstances to bother.) Dr EyeCandy told me that he'd had that happen with a few of his patients who tried it.
> ('Course, just 'cause it happened to me doesn't mean that GG wouldn't be more average in this. Just wanted to mention that it can't be relied upon to be sedating...)
> Hi, Panda! Good to see you!
That's alpha-2 NE antagonism kicking in, I hate it too. For me 15mg was bliss, when I increased to 30mg they became angry pills & it took me months to get use to it. :)
Remeron at low doses is a powerful H1 antagonist, at moderate doses it blocks 5-HT2 & 5-HT3, as you increase further, Alpha-2 NE antagonism kicks in & this is why higher doses are supposed to be stimulating. I guess the majority of people like A2 antagonism, but people like us don't. It's the reason I suggest people start low & creep up on the doseage slowly rather than going straight to a high doseage. I also urge people to try 22.5mg because 15, 22.5 & 30mg do distictly different things for me.