Posted by zeugma on July 28, 2004, at 4:22:30
In reply to Re: Imipramine vs ..King Vulcan, posted by banga on July 28, 2004, at 0:18:18
> Thanks for the input!
> How would then Nortriptyline be regarded for ADD symptomology? Isn't dopamine regulation also important for ADD? I ask because I at least in terms of Effexor didn't seem to benefit from the norepinephrine boost...but who knows? thats just one drug. And I drink coffee like you wouldnt believe-supposedly affects norepinephrine--it wires me slightly physically but its my anxiolytic like cigarettes are for others.
Nortriptyline and other NE reuptake inhibitors help ADD/concentration and boost DA along with NE because the NE transporter actually has a higher affinity for DA than NE. So in regions where DA clearance is mediated by the NE transporter (notably the prefrontal cortex) NE reuptake blockers prolong the action of DA.Also, 5-HT2A antagonism causes DA to rise in the cortex. Atypical AP's as well as TCA's do this, and this helps with the 'negative symptoms' of schizophrenia as well as depression (apathy, executive dysfunction).
poster:zeugma
thread:370994
URL: http://www.dr-bob.org/babble/20040724/msgs/371517.html