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Re: Imipramine vs desipramine vs clomipramine? » banga

Posted by King Vultan on July 27, 2004, at 8:08:27

In reply to Imipramine vs desipramine vs clomipramine?, posted by banga on July 27, 2004, at 0:10:08

Desipramine is regarded as the best one for ADD because it is a relatively powerful norepinephrine reuptake inhibitor, but I have also seen an anecdote from an individual who found imipramine quite effective. Imipramine is a combined norepinephrine/serotonin reuptake inhibitor with other points of action also. It would be both more sedating and more anxiolytic than desipramine; it is also more anticholinergic, being especially noted for causing dry mouth. Clomipramine is a tricyclic SSRI and is quite effective in that respect but would not be particularly great for ADD, just as regular SSRIs are not indicated for this either. For ADD, it is thought that the norepinephrine system is the one that is important; serotonin is more involved with anxiety related disorders such as OCD and PTSD.

Todd


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