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Re: Histamine H1 - Drugs to increase activity? Questionmark

Posted by Larry Hoover on July 22, 2004, at 6:17:48

In reply to Re: Histamine H1 - Drugs to increase activity? SLS, posted by Questionmark on July 22, 2004, at 4:58:25

> > Hi.
> >
> > I am interested in how histaminergic pathways might be involved in depression and bipolar disorder. Are there any drugs that act as H1 receptor agonists or otherwise promote histaminergic neurotransmission? Do such things exist?
> >
> >
> > - Scott
> Very novel and interesting thought, Scott. i've been curious as to what a histamine agonist might be like for awhile as well, though maybe not to the extent that you have. It would be very interesting to try one though, if one were available. Unfortunately, i have never heard of one, selective or not.
> Take care.

Sorry for any confusion I may have added to this thread, but my brain has been misfiring lately, apparently due to Zoloft. In some instances, I was reading affinity, but thinking agonism.

However, there is a potent H1 agonist, 8R-lisuride. There are also some histamine analogs with higher agonistic potential than histamine itself.

Perhaps more useful, though, from a pharmacological standpoint, are drugs which agonize or antagonize the H3 histamine synaptic autoreceptor. It directly regulates histamine synthesis and release in the brain. I believe there are H3 drugs entering the clinical trial arena round about now.





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