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Re: Histamine H1 - Drugs to increase activity? SLS

Posted by Larry Hoover on July 20, 2004, at 9:47:31

In reply to Re: Histamine H1 - Drugs to increase activity?, posted by SLS on July 19, 2004, at 13:44:26

> I really don't know yet. I am just starting to look into it. Right now, the best I can do is to skim a few paragraphs here and there. I can't remember the last time I was able to read word for word three consecutive paragraphs. I am becoming interested in the DLPFC (dorsolateral prefrontal cortex) as being the site most affected in my case. Some of the afferent circuits are histaminergic. I am curious if any pro-histaminergic drugs have been screened for depression.
>
>
> - Scott

Well, pace yourself. Don't push yourself to exhaustion. It isn't worth it. What you can do is what you can do.

There are a number of antidepressants which have been found to coincidentally hit H1 receptors: Remeron, doxepin, trimipramine, amitryptiline. I don't know about pure H1 activity, off the top of my head. There are anecdotal reports that some of the modern antihistamines have some selective H1 activity, notwithstanding their advertised "non-drowsy" status, but I can't remember which one (or ones). Benadryl (diphenhydramine) is a non-specific histaminic, but tolerance often very quickly develops to it. If you try a dose of Benadryl just before retiring for the night, and you awake feel more restored by sleep, maybe that will be the sort of clue you're looking for?

Lar

 

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poster:Larry Hoover thread:367673
URL: http://www.dr-bob.org/babble/20040719/msgs/368174.html