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Re: Histamine H1 - Drugs to increase activity?

Posted by SLS on July 19, 2004, at 13:44:26

In reply to Re: Histamine H1 - Drugs to increase activity? SLS, posted by Larry Hoover on July 19, 2004, at 9:59:05

> > I am interested in how histaminergic pathways might be involved in depression and bipolar disorder. Are there any drugs that act as H1 receptor agonists or otherwise promote histaminergic neurotransmission? Do such things exist?

> Yes, H1 histamine agonists are known. One of the central roles of histamine in the brain is as a participant in the diurnal wake/sleep cycle. For an H1 agonist drug to be useful, IMHO, its uptake and clearance time must also be in accord with the oscillations in e.g. melatonin, HGH, cortisol release which accompany movement through this cycle. Histamine does other things, too. Just what aspect of histamine function would you be trying to tweek?

I really don't know yet. I am just starting to look into it. Right now, the best I can do is to skim a few paragraphs here and there. I can't remember the last time I was able to read word for word three consecutive paragraphs. I am becoming interested in the DLPFC (dorsolateral prefrontal cortex) as being the site most affected in my case. Some of the afferent circuits are histaminergic. I am curious if any pro-histaminergic drugs have been screened for depression.

- Scott




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