Posted by zeugma on July 6, 2004, at 22:16:06
In reply to Re: Nortriptyline Experiences » Sad Panda, posted by SLS on July 6, 2004, at 21:56:10
Hi Scott and Panda,
I've never had an ECG performed or had a dr. ask me about it either. The only problem I have experienced in connection with nortrip is lowered bp, so I was advised to eat salty foods and keep myself well hydrated, which solved the problem. I get my bp monitored every month.
Scott:
I suspect strongly that AD efficacy is connected to REM suppression,and/or changes in NREM, though I don't have anything on hand to suggest that loss of efficacy is due to tolerance to REM suppression. What little evidence I've seen connected to poopout (not related to REM) suggests that it develops more frequently with MAOI's than TCA's.
I haven't come across anything in the narcolepsy literature that suggests that TCA's lose efficacy in the suppression of cataplexy (which is the intrusion of REM atonia into waking). Narcolepsy is a lifelong condition, and TCA efficacy is directly connected to suppression of REM, so there must be some anecdotal evidence somewhere that is relevant to your concern.
Poopout as a phenomenon only seems to have become the focus of attention lately, and primarily in connection with SSRI's.
Have you spoken to your doctor about the tolerance to REM suppression effects? Maybe he or she could shed some insight on the matter.
z
poster:zeugma
thread:363009
URL: http://www.dr-bob.org/babble/20040704/msgs/363609.html