Posted by jodeye on June 30, 2004, at 21:22:38
Hi Chemist,
My Dr. said he is now willing to prescribe anything as long as there is at least a small rationale for doing so (for social phobia and hypersomnia).
Several babblers have reported success preventing Adderall tolerance by adding an NMDA antagonist such as memantine, acamprosate, or dextromethorphan.
I am a non-responder to Adderall up to 40mg, except for negative peripheral effects. I have read preclinical statements that memantine can prevent stimulant sensitization, but nothing about tolerance. I have also read that sensitization is often considered to be related to the negative effects, and tolerance related to the positive effects. Maybe my negative response to Adderall could be considered as a preexisting sensitization?
Is the above in agreement with what you know about amphetamines?
Are you able to find anything in the literature that could be considered a rationale for combining amphetamine and an NMDA antagonist?
Thank you.
--Jay
poster:jodeye
thread:362148
URL: http://www.dr-bob.org/babble/20040627/msgs/362148.html