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Re: Thanks Chemist

Posted by paulbwell on June 30, 2004, at 3:37:22

In reply to Re: Thanks Chemist » Sad Panda, posted by chemist on June 29, 2004, at 2:08:43

> > > hi there, chemist here....desoxyn = (S)-methamphetamine, and dexedrine = d-amphetamine. panda is correct in re: potency. there is a body of literature that reports that methamphetamine is about twice as potent as d-amphetamine. potency is derived from dose/response evaluations of subjects, and i can point you to several citations that conclude that (S)-methamphetamine and d-amphetamine are actually equipotent. HOWEVER, it turns out that (in at least 1 study examining a D_{1} antagonist) the mechanisms of neurotoxicity at high doses of desoxyn and dexedrine are different, as the antagonist protected against death from dexedrine in a dose-dependent fashion but not for desoxyn. (Derlet et al., Life Sci. 47:821-827 (2000)). but, the equipotency has been established, too. [e.g., Woolverton et al., Pharmacol. Biochem. Behav. 13:869-876 (1980)]. but then, see Peachey et al., Psychopharmacology 51:137-140 (1977) for evidence of greater stimulation (not potency) of desoxyn than dexedrine. more recently, Melega et al. JPET 274:90-96 (1995) concluded that low doses of either drug exhibited similar pharmacokinetics and dopamine response, although this is not a measure of potency nor were the doses extreme. from an abstract by Ellison and Switzer in Neuroreport. 25:17-20 (1993), they report (i quote) ``Both [dexedrine] and [cocaine] induced pronounced degeneeration in fasciculus retroflexus, but only [dexedrine] further induced substantial degeneration in striatum...[Desoxyn] administered in the very high dose but less prolonged drug regimen often employed in studies of dopamine toxicity induce pronounced degeneration in striatum, but widespread degeneration in many other regions as well.'' and then there is one paper by the man who instigated the FDA to make MDMA illegal: Ricaurte et al., Neuropharmacology 22:1165-1169 (1983), in which ``Repeated administration of large doses of [desoxyn] produce long-lasting depletion of brain dopamine and serotonin, as well as persistent decreases in the activity of their respective biosynthetic enzymes...'' interestingly, dexedrine - in ``a comparable regimen'' to the desoxyn dosing - ``did not did not produce long-lasting depletion of 5-HT in either the neostriatum or hippocampus.'' but, it turns out (and not just in this ref) that pretreatment with fluoxetine likely inhibits metabolism of amphetamines in general. so, in summary: potency is derived from dose/response curves, and in low doses, it appears as if desoxyn and dexedrine exhibit similar pharmacokinetics and are somewhat equipotent. however, at high doses of both drugs, the potency of desoxyn is greater and the toxicity is, as well, due to the larger amount of the brain affected in re: dopamine and 5-HT response. most drugs exhibit linear pharacokinetics/dynamics in the recommended dose ranges. the LD_{50} for desoxyn and dexedrine are almost identical, but at higher doses, desoxyn is more lethal. finally, as i posted some time ago, the study by (again) Ricaurte et al. in Science 297:2260-2263 (2003) entitled ``Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA (``ecstact'')'' - which was later retracted because the drugs given to the 5 monkeys tunred out to be methamphetamine and not MDMA - is actually testament to the neurotoxicity to methamphetamine (desoxyn). the dose was 6 mg/kg over 6 hours. recalling that this was pure methamphetamine, this means that your 100 mg desoxyn would correspond to your weight at about 16 kg, or about 35 lbs. 1 monkey died, 1 was unable to continue after the second dose (dosing was 2 mg/kg tid), and the 3 surviving monkeys were examined over several weeks after the acute dosing (there's more, and i can send you the PDF of the article if you desire, or anyone else). conclusions: severe dopaminergic injury and serotonergic neuortoxicity (for subjects using methamphetamine in repeated doses over several hours). the implication is that using desoxyn for a prolonged period - which is essentially what this last study showed - is bad news compared to dexedrine. hope this helps, and all the best, chemist
> > >
> > >
> >
> > Thanks for that Chemist, I thought methamphetamine was neurotoxic when compared to d-amphetamine but I didn't know it was that bad. Regardless of it being called Desoxyn, Methedrine or methamphetamine, I thought it was pretty safe to assume we are talking about actual methamphetamine & not adulterated street meth since this isn't the substance abuse board & we only talk about legal drugs here.
> >
> > Cheers,
> > Panda.
> >
> >
> hey panda, thank you....still some unresolved issues with another poster who is intent on getting Desoxyn.....in my opinion, alternatives are better.....chat more anon, chemist
>

Hi Chemist, who would be this poster intent on gettin Desoxyn? Its a heavy hitter im sure, and Im sure in 90% of cases you would know about the better alternatives.

-Im curious you seem very knowlegdeable, are you an experienced Pharmacist?


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URL: http://www.dr-bob.org/babble/20040627/msgs/361885.html