Posted by King Vultan on June 24, 2004, at 7:56:58
In reply to Best dopaminergic for..., posted by Questionmark on June 24, 2004, at 3:12:27
> What do you think the best dopaminergic drug for anorgasmia would be? This includes efficacy, lack of side effects, increased cognitive function, increased drive/motivation, lack of aggravation of anxiety or depression, and etc. Oh, and apart from aminaptine, apomorphine, and maybe cabergoline, since they are not available in the U.S. (unless cabergoline is [?]). Oh and i'm on Nardil so i couldn't take selegeline with it.
> Methylphenidate, bromocriptine, parlodel (sp?), pemoline, pramipexole, ropinirole, pergolide, other?
> Mucho mucho thanks to anyone who can help.
As Panda mentions, a 5HT-2 blocker might really be what you're looking for. Stahl in "Essential Psychopharmacology" says that the specific problem of anorgasmia is related to stimulation of 5HT-2A (serotonin 2A) receptors in the spinal cord. You are experiencing this on the Nardil because it is a very serotonergic medication, and this is likewise a notorious side effect of SSRIs such as Lexapro also.Remeron would be a good 5HT-2A blocker to try, but this drug does have significant side effects, especially weight gain. If you really want to try a dopaminergic drug, I suppose you could (cautiously and carefully) add a stimulant; these would also increase your cognitive focus and drive. There is a considerable amount of anecdotal information that the dopamine agonists such as bromocriptine and pramipexole (also cabergoline, which is available in the US but is extremely expensive) can have a very beneficial effect on libido, but I question if they would do as well on anorgasmia. They also tend to have significant side effects, particularly somnolence and nausea.
Todd
poster:King Vultan
thread:359682
URL: http://www.dr-bob.org/babble/20040621/msgs/359713.html