Posted by zeugma on June 12, 2004, at 10:57:51
In reply to Re: Anyone with knowledge about O.C.D. medications? » zeugma, posted by don_bristol on June 12, 2004, at 9:02:25
> >> think you mean Anafranil. It is the TCA most likely to work for OCD, and some claim it is the most potent AD, period.<<
>
> Zeugma, do you have any refernces or links for suggestions that Anafranil is cponsidered by some to be the most potent AD. Thank you.Hi Don, this is an excerpt from the site http://www.psychotropical.com
Antidepressants - Clomipramine
Date Created: 29/09/2000 Last Modified: 18/05/2002 Last Checked: 21/10/2002
It seems ironic that despite all the new drugs that have arrived in the last decade of the last millennium some of the best evidence for superior efficacy is for the older ones (especially clomipramine and clozapine).Clomipramine was the first, and for some while the only drug (till fluoxetine 1986), that was effective for obsessive compulsive disorder. This was first noted around 1966, the French take the credit for that. The French also were the first to observe the mood stabilising effect of anti-epileptic drugs as well as the anti-psychotic effect of chlorpromazine, to mention but some of their firsts; funny how infrequently those 'firsts' are referenced and quoted; it is an anglo-centric world. The Brits and others were several (that is being kind) years behind.
It is quite extraordinary to reflect that it took the USA and Australia (where clomipramine was not introduced until 1983) so long to appreciate the superiority of this drug. The implications that has for scientific progress in psychiatry hardly require elaboration and certainly do not reflect credit on the discipline.
Clomipramine is effective for obsessive compulsive disorder almost certainly because it is a potent serotonin reuptake inhibitor, indeed more potent (in vitro) than most of the new serotonin reuptake inhibitors (SSRIs). It is metabolised into desmethyl-clomipramine which, like desipramine (which is desmethyl-imipramine), is a potent noradrenalin reuptake inhibitor. >>>
The author of this site is an clinician with a strong interest in psychopharmacology.
Another poster on this site, whom I consider a reliable source of info on medication, said that his pdoc considered CMI the most potent AD, and the poster's own experience bore this out.
I was planning to try CMI myself, when it seemed that I was experiencing a severe relapse lately. That has abated some, but I would have no hesitation in suggesting it to a pdoc should my symptoms return with the same virulence.
I researched CMI extensively during the period of my relapse, and uncovered some other interesting information pertaining to CMI's effectiveness. I will try to find some other of these references, and post them as soon as I can.
poster:zeugma
thread:355794
URL: http://www.dr-bob.org/babble/20040608/msgs/356052.html