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Re: Effexor withdrawal/spaciness/desipramine help! » Chairman_MAO

Posted by Questionmark on June 12, 2004, at 3:55:40

In reply to Effexor withdrawal/spaciness/desipramine help!, posted by Chairman_MAO on June 9, 2004, at 13:05:58

> I'm on day 8 of both desipramine 75mg/day and Effexor withdrawal from 75mg/day. I'm doing some temp work in data entry these days and feel mentally incapacitated. Even tasks sequences, such as pressing the tab key, following the cursor from one field to another, and then looking at the appropriate space on my hard copy to find the value I need to enter, are proving excrutiatingly difficult! I'm so spacey I feel like I'm in waking dream! Hell, simply writing this posting is proving more difficult than I anticipated, as it always feels as if all my sentence structures are suboptimal. That's not even the word I wanted to use--or it doesn't feel like it--but I have to put SOMETHING down for all of you to try to understand!
>
> I quit the Effexor in favor of desipramine primarly because serotonergic drugs without dopaminergic augmentation--which my pdoc will notgive me--make my ADD much, much worse. Well, now I'm even foggier than ever! There are so many possible factors at work here:
>
> 1) desipramine causing cognitive dysfunction due to its anticholinergic effect (didn't notice this the last time I tried it)
>
> 2)Trileptal 900mg/day, which I had to start taking again to keep myself from randomly crying during the withdrawl
>
> 3) Effexor withdrawal
>
> etc etc etc. I guess I'm just wondering if anyone else has experienced similar cognitive dysfunction upon withdrawal of a serotonin reuptake inhibitor, and, if so, how long did it last?
>
> Thanks for your support.


i definitely experienced cognitive dysfunction after quitting Paxil last year. It was a bizarre & horrible sort of cog dysfunction though-- not like from an antihistamine or benzo or something. It was like i could not control my thoughts and where my mind wandered-- i could not think clearly at all. It was horrible. My situation was (unfortunately, for me) pretty unique for some reason, however, in that this effect and the horrible despair & etc. from the withdrawal did not go away for months. i did not feel better until i finally started Nardil.
But anyway, so yeah i definitely think that the Effexor withdrawal can be causing a lot of your cognitive difficulties. If it's possible i think taking a low dose of Prozac for a little while would be beneficial (b/cz of the long half-life).
Also, the Trileptal may definitely be aggravating this as well. So this should be good though-- once you get over the Effexor withdrawal and once you stop taking the Trileptal, your cognitive abilities should return to normal or better (especially, i imagine, once the desipramine starts working well).


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