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SSRI and low-dose selegeline-- beneficial, safe?

Posted by Questionmark on May 25, 2004, at 6:54:33

Please give me your thoughts and opinions people.

Okay. i am on the blessed Nardil and experiencing its tremendous benefits, but i am really starting to get sick of the anticholinergic and anorgasmic side effects. And every drug i try-- to help alleviate them, particularly the latter s.e.-- is insufficiently effective and has troublesome side effects of its own.
So a thought occurred to me the other day: What if one just took an SSRI with a low dose of selegeline (e.g., 5-15mg)? That way s/he would have all the benefits of the SSRI (assuming that the person responds well to an SSRI) in addition to the dopaminergic, apathy-preventing, motivational, procognitive, prosexual, anti-anorgasmic properties of selegeline. Also, the SSRI would hopefully help counteract/balance the emotional over-sensitivity and agitating and anxiogenic effects that selegeline might have.
Also-- well actually i was just assuming that it lacks anticholinergic effects but i really do not know, but-- since, or if, selegeline has minimal anticholinergic effects, then you would not only (hopefully) have a wonderfully effective med combination, but you would have it without the annoying hassle, discomfort, and difficulty of anticholinergic side effects. Now i know that the vast majority of pdocs would not prescribe this combination-- since they are too unfamiliar with it and therefore lack the courage to cautiously experiment with the idea, and since MAOIs and SSRIs are HIGHly contraindicated, due to the ease of developing serotonin syndrome (although at doses that only inhibit MAO-B-- if it is indeed "only"-- then this would not be a significant risk). But i wonder if it might not be an extremely worthwhile treatment.

What do you think? Am i being completely naive and/or ignorant about certain factors, or is this a potentially useful treatment combination? Why or why not?
Thanks alot if you take the time to answer.




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