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Re: zoloft at high doses

Posted by collegeguy on May 24, 2004, at 12:46:37

In reply to zoloft at high doses, posted by dondon on May 24, 2004, at 12:18:21

No no no no, that is a BAD way to approach it. Taking Remeron (which increases serotonin in two ways) and Zoloft at such a high dose is asking for serotonin syndrome, which is no fun at all.

Zoloft, while it has a longer half-life than some of the other SSRIs will not really be effective if taken that sparsely. And if you happen to metabolize Zoloft faster than normal, bouncing the drug levels around in your body like that could result in quasi-withdrawal every 2-3 days.

Zoloft is a weak inhibitor of dopamine and should not be taken for an "amphetamine-like effect" (esp. in combo with remeron). If you need more energy, have your doctor prescribe an amphetamine like Dexedrine (which is mostly dopamine stimulating), or a med like Ritalin (which is a DA reuptake inhibitor, plus DA and NE stimulant).

And while these meds may linger in your system for 2-3 days, they'd do so at *very* weak levels. Dexedrine is out of your system in less than six hours, and that is when taken in spansule form (extended release bead filled capsule). The other psychostimulants are the same. They only last a while (a while being 12 hours if you are lucky) in your system because they've been coated with fancy release mechanisms, like the osmotic pump of Concerta.




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