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Re: selegiline ONLY (Chemist, KingVultan, SLS??)

Posted by SLS on May 24, 2004, at 8:52:34

In reply to selegiline ONLY (Chemist, KingVultan, SLS??), posted by platinumbride on May 23, 2004, at 14:13:37

I guess it is worth a try. It is hard to ignore the many reports of the successful use of selegiline to treat depression.

I have seen arguments made for the use of either tyrosine of phenylalanine as an adjunct. Tyrosine is one step closer than phenylalanine to synthesizing neurotransmitters. However, using phenylalanine produces an increase in PEA through a side-reaction, perhaps adding a stimulant-like mood brightening effect. These are rather simplistic arguments, and I don't know that there have ever been studies to compare the two. In the past, there have been posters here on PB who have demonstrated much greater expertise on this subject than I. You might have some luck using the PB/Google search using "AndrewB" and "Adam" as a keywords. You are bound to find a few threads.

Try this:

Historically, selegiline has not been considered to be a very effective antidepressant, although that is what it was initially developed as. Nevertheless, there have always been a few psychopharmacologists whom have embraced selegiline. When treating depression, the dosage of selegiline necessary to elicit an antidepressant response is higher than when it is used for Parkinsons.


20-60mg (oral)
20mg (transdermal patch)

When taking selegiline orally at dosages above 10mg, it is recommended that one follow a special tyramine restricted diet. Supposedly, this is not necessary when using the transdermal patch.

It is my impression that selegiline is not as potent an antidepressant as Nardil or Parnate. The bottom line is that no one here is smart enough to predict with certainty whether or not selegiline will work for you.

Good luck.

- Scott




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