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Re: selegiline ONLY (Chemist, KingVultan, SLS??)

Posted by elleff on May 24, 2004, at 0:34:16

In reply to Re: selegiline ONLY (Chemist, KingVultan, SLS??) platinumbride, posted by chemist on May 23, 2004, at 22:37:14

> > I guess some ppl have read my selegiline compounded into a cream posts and seen that I can't be bothered with the uncertainty of it.
> >
> > I talked to my doc about an maoi, taken in the traditional pill form and mentioned that I wanted to try parnate. He patently refused to prescribe any maoi except for selegiline. He also prescribed an amoino acid (phenyalenine??) along with it.
> >
> > I have been trying to find things out about this, but everything I read about seleg. in a pill form deals with parkinson's or alzheimer's diseases, and I have only seen one thing about the seleg/phen. study.
> >
> > Does anyone have any experience with selegiline as an antidepressant? Or with the combination I described above?
> >
> > Thanks,
> > Diane
>
> chemist here....i cannot think of any reason why you should be taking phenylalanine...there is a tie-in with L-tyrosine, but essentially you have been prescribed a component of an artificial sweetener for food/drinks. the presence of a primary amine does not overshadow the carboxylate group...i would respectfully ask about L-tyorsine in lieu of phenylalanine....all the best, chemist

Maybe there could be some sense behind it from the perspective that

1. The principle substrates for MAO-B in the brain are dopamine and PEA, which functions as a catecholaminergic enhancer. PEA is derived from phenylalanine I understand.

2. Sabelli's very positive studies of treatment resistant depressives using combinations of either selegilene and PEA or selegilene and phenylalanine in the 1980s.

Diane, be sure to take your phenylalanine on a completely empty stomach because amino acid transport into the brain is competetive and consequently other protein in the diet will reduce it's effectiveness.

regards

elleff


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